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Clinical Manifestations.

Floor Duits1,2, Paula I Vanneste2,3, Niki S M Schoonenboom4

  • 1Alzheimer Center Amsterdam, Department of Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, Netherlands.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Blood-based biomarkers (BBMs) show promise for improving Alzheimer's disease (AD) diagnosis. These studies will assess the clinical impact and utility of BBMs in Dutch memory clinics, aiming to enhance diagnostic accuracy and speed.

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Area of Science:

  • Neurology
  • Biomarker Research
  • Clinical Diagnostics

Background:

  • Alzheimer's disease (AD) diagnosis is often delayed and inaccurate in clinical practice.
  • Blood-based biomarkers (BBMs) offer a promising avenue for accurate AD detection.
  • There is a need for real-world evidence on the clinical impact of BBMs.

Purpose of the Study:

  • To investigate the clinical impact and diagnostic utility of BBMs for AD in memory clinics.
  • To gather real-world evidence on implementing BBMs in clinical practice.
  • To develop appropriate use criteria for BBMs in Dutch memory clinics.

Main Methods:

  • Two studies are designed: a diagnostic randomized controlled trial (n=550) and a pragmatic study (n>450).
  • The diagnostic trial will assess the impact of disclosing p-tau217 and serum NfL results on patient management, diagnosis, and time to diagnosis.
  • The pragmatic study will evaluate the impact of BBMs on clinicians' decision-making in routine practice.

Main Results:

  • IRB approval is pending; recruitment is expected to start in Q1 2025.
  • Currently, CSF or PET biomarkers are not routinely used in memory clinics (0-25% of cases).
  • Hypothesis: BBMs will improve diagnostic accuracy, confidence, and shorten the time to diagnosis.

Conclusions:

  • AD BBMs are rapidly advancing towards clinical practice with potential for substantial impact.
  • Memory clinic physicians recognize the advantages of BBMs.
  • These studies will facilitate familiarity and the development of BBM use criteria in Dutch memory clinics.