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Published on: September 20, 2018
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Clinical Manifestations
Olivier Fortier-Lebel1,2,3, Émilie Hudon1,2, Sarah Brosse1,2
1Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
Summary
Individuals with subjective cognitive decline (SCD) show poorer olfactory function and higher anxiety and depression levels. These factors together improve the prediction of SCD status, suggesting early preclinical Alzheimer's Disease detection.
Area of Science:
- Neuroscience
- Gerontology
- Psychiatry
Background:
- Subjective cognitive decline (SCD) is a preclinical stage of Alzheimer's Disease (AD).
- Olfactory dysfunction and neuropsychiatric symptoms are linked to AD progression.
- Little is known about these impairments in the SCD stage.
Purpose of the Study:
- To investigate olfactory function in individuals with SCD.
- To assess anxiety and depression levels in SCD.
- To compare SCD participants with healthy controls.
Main Methods:
- 110 participants (59 SCD, 51 controls) aged 60+ were recruited.
- Anxiety (GAI) and depression (GDS) were assessed.
- Olfactory testing used the Sniffin' Sticks battery.
Main Results:
- SCD group had significantly lower global olfactory performance than controls.
- Anxiety and depression scores were higher in the SCD group.
- Combined olfactory, anxiety, and depression data improved SCD prediction accuracy.
Conclusions:
- Individuals with SCD exhibit objective olfactory deficits.
- Olfactory function, anxiety, and depression are relevant in early AD stages.
- Further research into olfactory event-related potentials is warranted.
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