Related Experiment Video
Updated: Jan 7, 2026
07:50
A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
16.4K
Clinical Manifestations
Haoran Zhang1,2, Yingqi Liao3, Haoxuan Wen4
1School of Public Health, the Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
Summary
Comorbidity of midlife and late-life mood symptoms, including depression and bipolar disorder, significantly increases dementia risk and accelerates onset. These symptoms also correlate with cognitive decline and metabolic dysfunction.
Area of Science:
- Neuroscience
- Psychiatry
- Gerontology
Background:
- Mood disorders like depression and bipolar disorder are linked to dementia.
- Early manic symptoms of bipolar disorder are often overlooked.
- Investigating midlife and late-life mood symptoms' link to dementia is crucial.
Purpose of the Study:
- To examine the association between midlife/late-life mood symptoms, particularly their comorbidity, and long-term dementia risk.
- To analyze the impact on cognitive function and metabolomics.
Main Methods:
- Utilized UK Biobank and three Asian studies for discovery and validation.
- Included participants over 35, excluding those with diagnosed mood disorders or dementia at baseline.
- Classified mood symptoms (normal, manic, depressive, comorbidity) and analyzed 12-year dementia incidence using Fine-Gray models.
Main Results:
- Comorbidity of depressive and manic symptoms significantly elevated dementia risk (sHR=9.46) and hastened onset by 1.6 years.
- Prevalence of mood symptoms was high among dementia patients (11.4%-31.2%).
- Symptom comorbidity was linked to poorer cognitive function and exacerbated metabolic dysfunction.
Conclusions:
- Mood symptom comorbidity in midlife and late-life elevates cumulative dementia risk.
- Findings highlight the importance of recognizing and managing mood symptoms for dementia prevention.
- Further research into distinct pathophysiological mechanisms is warranted.
Related Concept Videos
01:24Chronic Kidney Disease II: Clinical Manifestations
520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
01:30Coronary Artery Disease III: Clinical Manifestations
299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
01:25Endocarditis II: Clinical Features of Infective Endocarditis
364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
01:26Heart Failure III: Clinical Manifestations
436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
01:29Gastroesophageal Reflux Disease II: Clinical Features and Management
652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437