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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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Clinical Manifestations.

Haoran Zhang1,2, Yingqi Liao3, Haoxuan Wen4

  • 1School of Public Health, the Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Comorbidity of midlife and late-life mood symptoms, including depression and bipolar disorder, significantly increases dementia risk and accelerates onset. These symptoms also correlate with cognitive decline and metabolic dysfunction.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Gerontology

Background:

  • Mood disorders like depression and bipolar disorder are linked to dementia.
  • Early manic symptoms of bipolar disorder are often overlooked.
  • Investigating midlife and late-life mood symptoms' link to dementia is crucial.

Purpose of the Study:

  • To examine the association between midlife/late-life mood symptoms, particularly their comorbidity, and long-term dementia risk.
  • To analyze the impact on cognitive function and metabolomics.

Main Methods:

  • Utilized UK Biobank and three Asian studies for discovery and validation.
  • Included participants over 35, excluding those with diagnosed mood disorders or dementia at baseline.
  • Classified mood symptoms (normal, manic, depressive, comorbidity) and analyzed 12-year dementia incidence using Fine-Gray models.

Main Results:

  • Comorbidity of depressive and manic symptoms significantly elevated dementia risk (sHR=9.46) and hastened onset by 1.6 years.
  • Prevalence of mood symptoms was high among dementia patients (11.4%-31.2%).
  • Symptom comorbidity was linked to poorer cognitive function and exacerbated metabolic dysfunction.

Conclusions:

  • Mood symptom comorbidity in midlife and late-life elevates cumulative dementia risk.
  • Findings highlight the importance of recognizing and managing mood symptoms for dementia prevention.
  • Further research into distinct pathophysiological mechanisms is warranted.