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Clinical Manifestations.

Sena Gok1, Salma Amarin1, Nicole Schoer2

  • 1CAMH, Toronto, ON, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

In Alzheimer's disease, functional impairment, not medication, significantly impacts fall risk in patients with neuropsychiatric symptoms. This highlights the need to focus on cognitive and functional status for fall prevention strategies.

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Area of Science:

  • Geriatric Medicine
  • Neurology
  • Clinical Pharmacology

Background:

  • Polypharmacy is prevalent in older adults with Alzheimer's disease and related dementias (ADRD) experiencing neuropsychiatric symptoms (NPS).
  • Medication's specific impact on fall risk in this population remains unclear despite associations with general increased fall risk.

Purpose of the Study:

  • To evaluate fall risk associated with psychotropic and general medication use in patients with ADRD and NPS.
  • To control for other clinical factors influencing fall risk in this cohort.

Main Methods:

  • Utilized data from the Standardizing Care for Neuropsychiatric Symptoms and Quality of Life in Dementia (StaN) study.
  • Assessed number of psychotropic/general medications, Cohen Mansfield Agitation Inventory (CMAI), Cumulative Illness Rating Scale-Geriatric (CIRS-G), Functional Assessment Staging Tool (FAST), and Morse Fall Scale (MFS).
  • Employed linear regression analyses adjusting for age, CIRS-G, CMAI, and FAST scores to examine associations with MFS.

Main Results:

  • 185 participants (mean age 80.5 years, mean FAST score 9.1) were analyzed.
  • Neither psychotropic nor general medication use showed a significant association with fall risk (MFS).
  • Functional Assessment Staging Tool (FAST) stage of dementia was significantly associated with fall risk.

Conclusions:

  • Functional and cognitive impairment, rather than medication, appears to be a more significant influence on fall risk in Alzheimer's disease.
  • Findings are specific to a cohort with severe dementia and significant NPS.
  • Results may inform fall risk management strategies for similar patient populations.