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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

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Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Biqi Wang1, Huitong Ding2,3, Derek Qi4

  • 1University of Massachusetts Medical School, Worcester, MA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Accelerated brain aging correlates with lower cognitive function and increased risk of Alzheimer's disease and stroke. Plasma biomarkers may help monitor brain health and identify at-risk individuals.

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Area of Science:

  • Neuroscience
  • Genomics
  • Biomarker Discovery

Background:

  • Brain aging is critical for understanding cognitive decline and neurodegenerative diseases.
  • Early detection of brain aging markers enables timely interventions for age-related neurological conditions.

Purpose of the Study:

  • To investigate the association between brain aging, cognitive function, and neurodegenerative disease risk.
  • To identify potential plasma-based biomarkers for monitoring cognitive health.

Main Methods:

  • Utilized UK Biobank proteomics data (Olink) and Framingham Heart Study (FHS) data (SOMAscan).
  • Calculated brain age, non-organ-specific age, and proteomic age using LASSO regression.
  • Assessed associations with cognitive function via linear regression and disease risk via Cox models.

Main Results:

  • Accelerated brain aging correlated with chronological age (r=0.72) and lower cognitive scores in 53,005 UK Biobank participants.
  • Accelerated brain aging increased risk for Alzheimer's disease (HR=1.88) and stroke (HR=1.30).
  • Replication in FHS showed association with lower attention (P=0.03) and increased stroke risk (HR=1.19).

Conclusions:

  • Brain aging is linked to cognitive performance and brain-related disease risk across two cohorts.
  • Plasma biomarkers show potential for monitoring cognitive health and identifying individuals at risk for neurological diseases.