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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Pulkit Khandelwal1, Michael Tran Duong1, Lisa M Levorse1

  • 1University of Pennsylvania, Philadelphia, PA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

We developed purple-mri, a novel package for analyzing postmortem brain MRI, revealing stronger associations between brain thickness and Alzheimer's disease pathology than antemortem scans. This tool facilitates large-scale postmortem studies and biomarker development.

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Area of Science:

  • Neuroimaging
  • Neuropathology
  • Medical Image Analysis

Background:

  • Postmortem MRI offers ultra-high resolution for detailed brain structure analysis, surpassing in vivo MRI capabilities.
  • A novel package, purple-mri, is introduced for tissue segmentation, anatomical parcellation, and spatial normalization of postmortem MRI data.
  • A framework for point-wise surface-based group studies is provided, linking morphometry and histopathology in a common coordinate system for postmortem MRI.

Purpose of the Study:

  • To present the purple-mri package for comprehensive postmortem MRI analysis.
  • To enable accurate parcellation and registration of postmortem cerebral hemispheres.
  • To demonstrate the utility of purple-mri in correlating brain morphometry with neuropathological markers.

Main Methods:

  • A joint voxel- and surface-based pipeline combining deep learning and classical techniques was developed for postmortem brain hemisphere analysis.
  • Deformable image registration was performed between antemortem and postmortem MRI using GM/WM segmentations.
  • Point-wise analysis correlated cortical thickness with tau and neuronal loss distribution in 49 matched specimens and an additional 26 postmortem scans.

Main Results:

  • The purple-mri method accurately parcellates postmortem brain hemispheres, including regions with low contrast or atrophy.
  • The registration pipeline established a one-to-one correspondence between antemortem and postmortem MRI modalities.
  • Postmortem MRI revealed significantly stronger associations between cortical thickness and tau/neuronal loss across large brain regions compared to antemortem MRI.

Conclusions:

  • The purple-mri package enables large-scale postmortem image analysis.
  • Stronger associations observed in postmortem MRI suggest its potential for developing more precise in vivo biomarkers.
  • Mapping postmortem findings to antemortem MRI in a common coordinate system can inform future diagnostic and therapeutic strategies for neurodegenerative diseases.