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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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Clinical Manifestations.

Nikita Cherkasov1, Igor Kolykhalov1

  • 1Mental Health Research Center, Moscow, Moskva, Russian Federation.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary

The Mild Behavioral Impairment Checklist (MBI-C) effectively identifies patients with mild cognitive impairment (MCI) at higher risk of dementia. Higher baseline MBI-C scores predict significant cognitive decline and dementia progression in Russian-speaking populations.

Area of Science:

  • Neuroscience
  • Geriatrics
  • Psychiatry

Background:

  • Mild behavioral impairment (MBI) is linked to increased dementia risk.
  • The informant-based Mild Behavioral Impairment Checklist (MBI-C) quantifies MBI.
  • This study assesses MBI-C utility in Russian-speaking patients with mild cognitive impairment (MCI).

Purpose of the Study:

  • To evaluate the Mild Behavioral Impairment Checklist (MBI-C) in a Russian-speaking population with mild cognitive impairment (MCI).
  • To determine if MBI-C scores can predict conversion to dementia.
  • To assess the MBI-C's role in tracking cognitive decline in MCI patients.

Main Methods:

  • Eighty-six MCI patients underwent clinical, neuropsychological, and behavioral assessments, including MBI-C, MoCA, and CDR.

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  • Follow-up assessments were conducted over three years to track conversion to dementia.
  • Statistical analyses included Wilcoxon signed-rank test and two-way ANOVA to evaluate MBI-C scores and dementia conversion.

    • Main Results:

    • Patients who converted to dementia had significantly higher baseline MBI-C scores than non-converters.
    • MBI-C scores, particularly in impulse dyscontrol, increased significantly over time in converters.
    • High baseline MBI-C scores significantly predicted cognitive decline (MoCA scores) and dementia progression.

    Conclusions:

    • The MBI-C is a valuable tool for assessing behavioral symptoms in Russian-speaking MCI patients.
    • MBI-C demonstrates predictive power for neurodegenerative disorder progression.
    • The MBI-C complements standard cognitive assessments in predicting dementia risk.