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Clinical Manifestations.

Ignacio Flores1,2, Carmela Tartaglia3,4, Gabor G Kovacs3,5

  • 1Neuroscience Institute, Favaloro Foundation, Buenos Aires, Buenos Aires, Argentina.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Corticobasal syndrome (CBS) is a progressive neurological disorder. Early identification of Alzheimer's Disease (AD) as a cause is crucial for timely intervention and management.

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Area of Science:

  • Neurology
  • Neuroscience
  • Cognitive Science

Background:

  • Corticobasal syndrome (CBS) presents with motor and cognitive decline, including apraxia and dystonia.
  • CBS can be an early sign of atypical Alzheimer's Disease (AD).
  • Distinguishing AD-related CBS (CBS-ADNP) from other causes like corticobasal degeneration is challenging, as memory impairment varies.

Purpose of the Study:

  • To detail history-taking, physical examination, and neurocognitive findings for early CBS-ADNP identification.
  • To differentiate CBS cases with potential AD etiology from other neurodegenerative causes.
  • To improve early diagnosis and management strategies for CBS patients.

Main Methods:

  • Review of clinical history and physical examination findings in CBS patients.
  • Analysis of neurocognitive profiles associated with different CBS etiologies.
  • Comparison of clinical presentations between CBS-ADNP and other CBS subtypes.

Main Results:

  • Specific patterns in history, examination, and neurocognition can suggest AD as the underlying cause of CBS.
  • Absence of severe memory impairment does not rule out AD etiology in CBS.
  • Early clinical assessment is key to distinguishing CBS-ADNP.

Conclusions:

  • Early clinical evaluation, including detailed history, physical exam, and neurocognitive testing, is vital for identifying CBS-ADNP.
  • This approach aids in differentiating AD-related CBS from other neurodegenerative conditions.
  • Improved diagnostic accuracy facilitates appropriate patient management.