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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Gursimar Bhalla1, Ashwati Vipin2, Nagaendran Kandiah2,3

  • 1Dementia Research Centre (Singapore), Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore, Singapore, Singapore.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Mild behavioural impairment (MBI) is linked to specific hippocampal subfield volume reductions. These associations vary between cognitively normal individuals and those with mild cognitive impairment (MCI).

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Area of Science:

  • Neuroscience
  • Gerontology
  • Radiology

Background:

  • Mild behavioural impairment (MBI) signifies early neuropsychiatric symptoms preceding cognitive decline in older adults.
  • MBI can co-occur with mild cognitive impairment (MCI), suggesting a complex relationship.
  • The link between hippocampal subfield volumes and MBI, especially in MCI, remains underexplored.

Purpose of the Study:

  • To identify hippocampal subfield volumes associated with MBI.
  • To investigate how MCI diagnosis influences the relationship between MBI and hippocampal subfield volumes.

Main Methods:

  • 3T T1-weighted MRI scans were acquired for 313 cognitively normal (CN) and 293 MCI participants.
  • Freesurfer software processed MRI data; the Mild Behavioural Impairment Checklist (MBI-C) assessed MBI across five subdomains.
  • Logistic regression analyzed MBI subdomains, hippocampal subfield volumes, and their interaction with MCI diagnosis, controlling for covariates.

Main Results:

  • Interest and mood subdomains were linked to reduced left/right parasubiculum and left CA3 body volumes.
  • Social subdomain impairment correlated with reduced left hippocampal tail volume.
  • Beliefs subdomain impairment was associated with increased right hippocampal fissure volume; diagnostic interactions modified these associations.

Conclusions:

  • Specific hippocampal subfield atrophy correlates with distinct MBI subdomains.
  • The relationship between MBI subdomains and hippocampal subfield volumes is modulated by clinical diagnosis (CN vs. MCI).