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Clinical Manifestations.

Juan-Camilo Vargas-González1,2, Martin Ingelsson1,2, David F Tang-Wai2,3

  • 1University Health Network, Toronto, ON, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Informant characteristics significantly influence Neuropsychiatric Inventory-Questionnaire (NPI-Q) scores in Alzheimer's disease (AD) patients. These findings are crucial as NPI-Q results guide AD treatment, yet informant factors are often overlooked.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Psychiatry

Background:

  • Neuropsychiatric symptoms (NPS) are common in neurodegenerative diseases like Alzheimer's disease (AD).
  • The Neuropsychiatric Inventory-Questionnaire (NPI-Q) is a key informant-based tool for assessing NPS in AD.
  • Previous research suggests informant characteristics can impact other AD assessments like the Clinical Dementia Rating (CDR).

Purpose of the Study:

  • To investigate how informant characteristics affect NPI-Q scores in individuals with mild cognitive impairment or dementia due to AD.
  • To analyze the influence of informant demographics and relationship to the patient on NPS assessment.

Main Methods:

  • Utilized data from the National Alzheimer's Coordinating Center Uniform Data Set (NACC-UDS).
  • Included participants with AD as the principal diagnosis.
  • Employed conditional growth models with multilevel linear regression analysis, considering NPI-Q scores, informant characteristics, CDR global score (CDR-GS), and Clinician Judgments of Behavioural Symptoms (CJbS).

Main Results:

  • Analysis included 21,276 participants across 56,301 visits.
  • NPI-Q scores were higher with female informants (0.39) and when informants were children (0.34) versus spouses/partners.
  • Increased visit frequency was associated with lower NPI-Q scores, while higher CDR-GS and CJbS correlated with increased NPI-Q scores.

Conclusions:

  • Informant characteristics significantly modify NPI-Q severity scores in AD patients within the NACC-UDS.
  • These findings highlight the clinical relevance of considering informant factors in NPS assessment and treatment planning for AD.
  • Current treatment strategies for NPS in AD may not adequately account for the influence of informant characteristics.