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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Gita Pathak1, Kumudu Subasinghe2, Robert Barber2

  • 1Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Depression significantly increases Alzheimer's Disease (AD) risk, with plasma biomarkers like GFAP, tau, and NfL showing links to neurodegeneration. These findings suggest shared biological pathways between late-life depression and AD.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Psychiatry

Background:

  • Late-life depression is linked to increased Alzheimer's Disease (AD) risk.
  • The biological connection between depressive symptoms and AD pathology is not well understood.
  • Investigating plasma biomarkers may clarify if depression reflects early AD neurodegeneration or a separate condition.

Purpose of the Study:

  • To examine plasma biomarkers for Alzheimer's Disease (AD) to understand shared neurobiological mechanisms between depression and AD.
  • To investigate the association between depression, AD, and plasma biomarkers GFAP, tau, and NfL.

Main Methods:

  • Utilized data from the Texas Alzheimer's Research Care Consortia (TARCC).
  • Assessed depression using the Geriatric Depression Scale (GDS) and collected medical history.
  • Analyzed plasma biomarkers (GFAP, tau, NfL) in a subset of participants using the Quanterix assay.

Main Results:

  • Recent depression was significantly associated with AD diagnosis (OR=2.50, p < 1.33x10⁻²⁰).
  • Higher Geriatric Depression Scale (GDS) scores correlated with AD diagnosis (OR=1.05, p < 1.25x10⁻⁹).
  • GDS-30 scores showed significant associations with GFAP, total tau, and NfL plasma levels.

Conclusions:

  • Significant associations exist between depression, AD diagnosis, and plasma biomarkers of neurodegeneration.
  • Shared neurobiological mechanisms between depression and AD pathology are suggested by these correlations.
  • Further validation with independent cohorts and stratified analyses are planned.