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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
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Clinical Manifestations.
1Xuanwu Hospital, Capital Medical University, Beijing, Beijing, China; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, Beijing, China.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
Summary
Autoantibodies in neurodegenerative dementia (ND) may have protective effects, enhancing daily living and frontal lobe function. Proteomics revealed 162 differentially expressed proteins linked to autoantibody status in ND.
Area of Science:
- Neuroscience
- Immunology
- Proteomics
Background:
- Neurodegenerative dementia (ND) is a progressive cognitive decline disorder.
- The role of autoantibodies in ND is debated, with potential for both harm and protection.
- This study investigates autoantibody-positive ND, exploring clinical features and molecular mechanisms.
Purpose of the Study:
- To analyze clinical characteristics of patients with autoantibody-positive ND.
- To investigate potential molecular mechanisms using proteomics.
- To identify proteins influencing neuropsychological characteristics in ND.
Main Methods:
- Included 13 autoantibody-positive ND patients, 13 autoantibody-negative ND patients, and 13 controls.
- Compared demographics, lab results, and neuropsychological scores.
- Utilized proteomic analysis to identify differentially expressed proteins (DEPs) and bioinformatics for pathway analysis.
Main Results:
- Autoantibody-positive ND patients showed similar overall cognition but better daily living and frontal lobe function than autoantibody-negative patients.
- Proteomics identified 162 DEPs associated with autoantibodies, enriched in endocytosis, ER processing, tight junctions, and cellular adhesion pathways.
- Specific proteins (ARRB1, CAPN2, PPP2R1A, UGGT1) showed varied effects on cognitive and daily living scores.
Conclusions:
- Provides novel insights into clinical and biological mechanisms of autoantibody-positive ND.
- Identifies potential protein biomarkers for neuropsychological characteristics.
- Suggests potential for personalized treatment strategies in ND.
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