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Clinical Manifestations.

Babak Khorsand1, Elham Ghanbarian1, Hailey J Andrews2

  • 1University of California, Irvine, Irvine, CA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

The Cognitive Function Index (CFI) can help identify cognitive impairment in older adults, correlating with objective measures like the TICS-m. Specific self-reported concerns, such as memory issues, predict mild cognitive impairment (MCI).

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Area of Science:

  • Gerontology
  • Neuroscience
  • Cognitive Psychology

Background:

  • Cognitive Function Index (CFI) and Modified Telephone Interview for Cognitive Status (TICS-m) are key tools for cognitive screening in older adults.
  • TICS-m is an objective, examiner-administered test, while CFI is a subjective, self-reported questionnaire.
  • The relationship between subjective cognitive concerns and objective cognitive function is not consistently defined, despite the prevalence of subjective concerns in older adults.

Purpose of the Study:

  • To examine the association between the CFI and TICS-m scores.
  • To evaluate the utility of self-reported cognitive concerns in identifying cognitive impairment among older adults.

Main Methods:

  • 128 participants from the Remote Cognitive Aging and Alzheimer's Disease REsearch (R-CARE) study completed both CFI and TICS-m assessments.
  • Mild cognitive impairment (MCI) was defined using an education-adjusted TICS-m cut-score.
  • Linear regression analyzed the CFI-TICS-m relationship; logistic regression assessed CFI items' ability to classify cognitively unimpaired (CU) versus MCI participants, adjusting for demographics.

Main Results:

  • Higher CFI scores were significantly associated with lower TICS-m scores (ß=-0.47±0.18, p=0.009).
  • 32% of participants were classified as MCI based on TICS-m scores.
  • Five CFI items predicted MCI classification: repeating questions (OR=1.88), needing memory help (OR=1.63), difficulty managing money (OR=1.77), activity difficulties (OR=1.58), and appliance use issues (OR=2.48).

Conclusions:

  • The CFI demonstrates significant association with TICS-m, suggesting its value as a complementary tool for cognitive impairment detection.
  • Specific self-reported CFI items, including memory difficulties and challenges with daily activities, are predictive of MCI.
  • The CFI's ease of use and brevity support its potential for remote cognitive screening and early detection in diverse populations.