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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Yue Wu1, Yining Liao2, Keyan Yu1

  • 1Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

This study developed an automated AI framework using speech data to detect cognitive impairment (CI). The system achieved 74% accuracy in cross-lingual Chinese validation, aiding early screening.

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Area of Science:

  • Computational linguistics
  • Artificial intelligence in healthcare
  • Neuroscience

Background:

  • Speech analysis offers an efficient method for early cognitive impairment (CI) detection, particularly for potential Alzheimer's Disease (AD).
  • Existing automated frameworks for CI screening lack external cross-lingual validation, especially for Chinese populations.

Purpose of the Study:

  • To develop and validate an automated AI framework for cognitive impairment screening using speech data.
  • To address the challenge of language inconsistency in cross-lingual CI detection.

Main Methods:

  • Utilized speech data from the Cookie Theft description task from the ADReSSo and STAR datasets.
  • Employed an AI framework incorporating Automatic Speech Recognition (ASR), Large Language Models (LLMs), and machine learning classifiers.
  • Conducted experiments with multi-lingual datasets to ensure cross-lingual applicability.

Main Results:

  • The automated framework achieved 74% accuracy and 75% Area Under the Curve (AUC) in external cross-lingual Chinese validation.
  • An ablation study confirmed the contribution of each module within the framework.

Conclusions:

  • The proposed AI framework enables fully automated cognitive impairment assessment.
  • This technology is highly beneficial for large-scale early screening and self-testing for cognitive health.