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Biomarkers.

Elise Saul1, Jade Lasserve1, Léa Chauveau1

  • 1Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", NeuroPresage Team, GIP Cyceron, Caen, France.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Alzheimer's disease (AD) and aging impact medial temporal lobe (MTL) networks. Amyloid-beta (Aβ) affects white matter integrity, influencing anterior-temporal (AT) functional connectivity, especially with high Aβ levels.

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Area of Science:

  • Neuroimaging
  • Neurodegenerative Diseases
  • Brain Connectivity

Background:

  • Medial temporal lobe (MTL) networks, anterior-temporal (AT) and posterior-medial (PM), are impaired in aging and Alzheimer's disease (AD).
  • Previous research indicated AT hyperconnectivity in AD and PM hypoconnectivity in aging, but structural connectivity remains unclear.
  • Understanding the structural underpinnings of these networks is crucial for elucidating their roles in cognitive decline.

Purpose of the Study:

  • To identify white matter fibers supporting the AT and PM networks.
  • To investigate the impact of amyloid-beta (Aβ) accumulation on these white matter fibers.
  • To examine the relationship between white matter fiber integrity and functional connectivity within these networks.

Main Methods:

  • Structural and functional connectivity of AT and PM networks were assessed in 89 healthy older adults using diffusion kurtosis imaging (DKI) and resting-state fMRI.
  • Perirhinal and parahippocampal cortices served as seed regions for correlation and tractography analyses.
  • Amyloid-beta (Aβ) deposition was quantified using Florbetapir-PET imaging.

Main Results:

  • The hippocampal cingulum and inferior longitudinal fasciculus were identified as key components of both AT and PM networks.
  • An inverted U-shaped relationship was observed between Aβ burden and white matter fiber integrity.
  • High Aβ levels were associated with a negative correlation between AT structural and functional connectivity, while low Aβ levels showed a positive correlation.

Conclusions:

  • Amyloid-beta (Aβ) significantly impacts the structural connectivity of the medial temporal lobe (MTL).
  • Aβ accumulation is linked to altered structural and functional connectivity within the anterior-temporal (AT) network.
  • These findings provide novel insights into the complex interplay between Aβ, structural integrity, and functional connectivity in the aging brain.