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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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Clinical Manifestations.

Georgia Gopinath1, Rachel Yep1, Tulip Marawi1

  • 1Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Subjective cognitive decline (SCD) is more prevalent and strongly linked to depression and anxiety in South Asian and Chinese older adults compared to White older adults. Self- and study partner reports of SCD were consistent across ethnic groups.

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Area of Science:

  • Neurology
  • Gerontology
  • Psychiatry

Background:

  • Subjective cognitive decline (SCD) is an early indicator of Alzheimer's disease.
  • SCD is understudied in diverse ethnoracial groups, especially Asian populations.
  • This study examines ethnic differences in SCD among Canadian older adults.

Purpose of the Study:

  • Investigate ethnic variations in SCD burden.
  • Analyze the association between self- and study partner-reported SCD.
  • Identify demographic and neuropsychiatric factors linked to SCD across ethnic groups.

Main Methods:

  • Utilized data from the Canadian Multi-Ethnic Research on Aging (CAMERA) cohort.
  • Assessed SCD using the self- and study partner-reported Cognitive Functioning Index (CFI).
  • Measured depression and anxiety symptoms and analyzed associations using linear regression, adjusting for covariates.

Main Results:

  • South Asian and Chinese participants reported higher SCD than White participants.
  • Self- and study partner-reported SCD were significantly associated across all participants.
  • Depression and anxiety symptoms showed stronger associations with SCD in South Asian and Chinese individuals.

Conclusions:

  • Self- and study partner-reported SCD are associated, irrespective of ethnicity.
  • SCD burden is greater in South Asian and Chinese older adults.
  • Ethnoracial differences and neuropsychiatric symptoms are crucial for assessing SCD in diverse populations.