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Clinical Manifestations.

Leticia Fernanda Palma1, Rebeca Carvalho Bom2, Pedro Henrique Moreira Victoriano1

  • 1Federal University of São Carlos, São Carlos, SP, Brazil.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Lower education levels are linked to poorer cognitive performance and increased Alzheimer's Disease (AD) risk in older adults. Promoting lifelong learning may help mitigate cognitive decline, particularly in Latin America.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Public Health

Background:

  • Education is a significant factor influencing neurocognitive disorders, especially in Latin America.
  • Educational attainment is strongly correlated with cognitive performance and cognitive reserve in older adults.
  • This study investigates the role of education in cognitive function and Alzheimer's Disease (AD) prevalence within a Brazilian population.

Purpose of the Study:

  • To analyze the impact of education on cognitive performance in cognitively unimpaired older adults and individuals with AD.
  • To examine the relationship between education level and AD diagnosis in a Latin American sample.
  • To understand how education influences cognitive reserve and overall cognitive function in aging populations.

Main Methods:

  • A quantitative, cross-sectional study involving 135 participants (86 cognitively unimpaired, 49 with AD).
  • Cognitive assessments included ACE-R, MMSE, and CERAD word list; sociodemographic data were collected.
  • Statistical analyses comprised descriptive statistics, t-tests, chi-square, and Pearson's correlation.

Main Results:

  • The AD group was older, had significantly lower educational attainment (≤8 years), and poorer performance on all cognitive tests.
  • Lower education levels were associated with higher AD prevalence, lower family income, and reduced physical activity.
  • A negative correlation was observed between cognitive performance and both age and educational level.

Conclusions:

  • Education significantly influences cognitive performance and cognitive reserve in older adults.
  • Lower educational attainment is linked to worse cognitive outcomes and a higher likelihood of AD.
  • Lifelong educational opportunities are crucial for mitigating cognitive decline, especially in the Latin American context.