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Clinical Manifestations.

Nilton Custodio1, Marco Malaga1, Diego Bustamante-Paytan1

  • 1Instituto Peruano de Neurociencias, Lima, Lima, Peru.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary

Dementia with Lewy Bodies (DLB) patients presenting with cognitive symptoms developed dementia earlier. However, initial symptoms did not worsen overall cognitive or behavioral severity in DLB progression.

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Area of Science:

  • Neurology
  • Neuroscience
  • Geriatrics

Background:

  • Dementia with Lewy Bodies (DLB) is characterized by alpha-synuclein accumulation.
  • Early DLB presentation is heterogeneous, impacting disease progression understanding.
  • This study examines initial clinical presentation in Peruvian DLB patients.

Purpose of the Study:

  • Investigate the impact of initial clinical presentation on DLB progression.
  • Compare DLB patient characteristics based on early symptoms (cognitive, motor, behavioral).
  • Analyze neuropsychological profiles and disease course in DLB.

Main Methods:

  • Retrospective study of DLB and Alzheimer's Disease (AD) patients.
  • Diagnosis via established clinical criteria; cognitive function assessed using MMSE, IFS, UDS.
  • Statistical analyses (ANOVA, chi-squared, regression) compared groups based on initial symptoms.

Main Results:

  • 46 probable DLB patients included; median diagnosis time ~5 years.
  • Cognitive symptoms most common initial presentation, followed by motor/behavioral.
  • DLB patients showed higher cognitive/behavioral scores than AD, with distinct visuospatial/executive deficits.

Conclusions:

  • DLB patients with initial cognitive symptoms progressed to dementia earlier.
  • Initial symptoms did not correlate with increased severity in specific cognitive/behavioral domains.
  • Understanding early DLB heterogeneity is crucial for prognosis.