Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence and Correlates of Steatotic Liver Disease Among People With HIV in Uganda.

Open forum infectious diseases·2026
Same author

Defining a shift estimand on forgivingness without domesticating forgiveness: Comment on Cowden et al.

SSM. Mental health·2026
Same author

Law enforcement responses to mental illness in rural Uganda: A qualitative study of practices, challenges, and opportunities for training.

PLOS mental health·2026
Same author

Long-term trends in HIV-related stigma among older adults with and without HIV: a cohort study from Mbarara, Uganda.

The Gerontologist·2026
Same author

Declining but increasingly concentrated HIV stigma in rural Uganda: population-based cohort study, 2014-2024.

medRxiv : the preprint server for health sciences·2026
Same author

Gabapentinoid Polypharmacy Among Medicare Beneficiaries During the Poststroke Recovery Period.

Health services research·2026
Same journal

Associations of self-reported obstructive sleep apnea with cognition and dementia risk in cognitively unimpaired middle-aged adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Cardiovascular-kidney-metabolic syndrome stage modifies the efficacy of intensive blood pressure control on cognitive outcomes: A post hoc analysis of SPRINT MIND.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Evidence of APOE4-related brain vulnerabilities in verbal memory systems in midlife women.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Changes in DNA methylation-based aging predicts brain damage and dementia and reflects life-course cardiovascular risk.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Elimination of tau tangles and soluble aggregates with the small molecule ACI-16664 prevents neurodegeneration in vivo.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K

Clinical Manifestations.

Jeremy A Tanner1, Roslyn Valdespino1, Tiffany F Kautz1

  • 1University of Texas Health San Antonio, San Antonio, TX, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Older adults living with HIV (PLWH) on antiretroviral therapy (ART) in Uganda show comparable cognitive function and Alzheimer's disease biomarker levels to those without HIV. Further research will monitor cognitive trends and Alzheimer's disease and related dementias (ADRD) in this population.

More Related Videos

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

Related Experiment Videos

Last Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

Area of Science:

  • Neuroscience
  • Gerontology
  • Infectious Diseases

Background:

  • Sub-Saharan Africa faces a growing aging population and increasing numbers of people living with HIV (PLWH) on antiretroviral therapies (ARTs).
  • Limited data exists on the intersection of aging, Alzheimer's Disease (AD), and HIV in Sub-Saharan Africa, unlike in the Global North where HIV is linked to neuroinflammation and cognitive decline.
  • This study addresses the data gap regarding cognitive aging and AD biomarkers in older PLWH in Uganda.

Purpose of the Study:

  • To investigate cognitive performance and plasma Alzheimer's disease and related dementias (ADRD) biomarkers in older people living with HIV (PLWH) well-treated on antiretroviral therapy (ART) in Uganda.
  • To compare cognitive function and ADRD biomarkers between PLWH and demographically matched HIV-negative individuals.
  • To establish baseline data for future longitudinal studies on cognitive aging and ADRD in this population.

Main Methods:

  • The Uganda Aging Cohort Study (UACS) prospectively enrolled PLWH on ART and age/sex-matched controls.
  • Cognitive function was assessed using the Ugandan Neuropsychological Battery and tablet-based Cognitive Assessment Tool (TabCAT), with Z-scores calculated for global cognition and specific domains.
  • Plasma biomarkers including p-tau217, Aβ42/40, GFAP, and NfL were measured, and cognitive impairment was defined using Jak/Bondi criteria.

Main Results:

  • 576 participants (mean age 60) completed the study; cognitive performance was comparable between PLWH and controls across most measures, with PLWH showing higher animal fluency scores.
  • A trend towards higher cognitive impairment frequency and elevated p-tau217 was observed in PLWH, but differences were not statistically significant.
  • No significant differences in plasma ADRD biomarkers (p-tau217/Aβ42, Aβ42/40, GFAP, NfL) were found between HIV serostatus groups.

Conclusions:

  • Older PLWH on ART in Uganda exhibit comparable cognitive performance and plasma ADRD biomarker levels to their HIV-negative peers.
  • Findings align with research suggesting lower cognitive impairment rates in virally suppressed PLWH.
  • Further longitudinal research is needed to track cognitive changes and ADRD prevalence in this aging cohort, particularly concerning p-tau217 trends.