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Related Experiment Video

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Clinical Manifestations.

Roos J Jutten1, Daniel Soberanes2, Hairin Kim2

  • 1Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Remote cognitive testing using the Boston Remote Cognitive Assessment of NeuroCognitive Health (BRANCH) shows promise for detecting early Alzheimer's disease (AD) changes. Lower BRANCH scores correlated with higher p-tau217 levels, indicating potential for scalable AD risk detection.

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Area of Science:

  • Neuroscience
  • Biomarkers
  • Cognitive Assessment

Background:

  • Early detection of Alzheimer's disease (AD) is crucial for effective secondary prevention strategies.
  • Innovative approaches combining remote cognitive assessments and blood biomarkers offer scalable solutions for identifying early AD-related cognitive changes.
  • The Boston Remote Cognitive Assessment of NeuroCognitive Health (BRANCH) was evaluated for its ability to detect cognitive changes linked to early AD pathophysiology, using plasma p-tau217 as a biomarker.

Purpose of the Study:

  • To investigate if the multi-day BRANCH cognitive assessment captures cognitive changes associated with early AD pathophysiology.
  • To determine the association between BRANCH cognitive assessment scores and plasma p-tau217 levels in cognitively unimpaired older adults.
  • To compare the sensitivity of BRANCH with a standard cognitive composite (PACC-5) in detecting early AD-related changes.

Main Methods:

  • 254 cognitively unimpaired older adults completed a multi-day BRANCH assessment on personal devices, including associative memory and processing speed tests.
  • A Multi-Day Learning Curve (MDLC) score was calculated for each test and averaged into a BRANCH Composite MDLC.
  • Linear regression models assessed the association between log-transformed plasma p-tau217 levels and BRANCH Composite MDLC scores, adjusting for relevant covariates.

Main Results:

  • Lower BRANCH Composite MDLC scores were significantly associated with higher plasma p-tau217 levels (corrected std. β = -0.23, p = 0.031).
  • The Digit Signs test within BRANCH primarily drove this association (corrected std. β = -0.22, p = 0.031).
  • No significant association was found between the Preclinical Alzheimer's Cognitive Composite (PACC-5) and p-tau217 levels (corrected std. β = -0.15, p = 0.187).

Conclusions:

  • Multi-day BRANCH assessments may enhance the detection of subtle memory deficits related to early AD pathophysiology.
  • Combining sensitive remote cognitive paradigms like BRANCH with plasma biomarkers can facilitate scalable detection of individuals at risk for AD-related cognitive decline.
  • BRANCH shows potential as a sensitive tool for early AD detection in remote settings.