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Clinical Manifestations.

Michelle Gerards1, Constanze Hübner2, Annika Baumeister2

  • 1Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Alzheimer's disease risk perception is highly individual. Personalized counseling is crucial for informed decisions about preclinical predictive diagnostics, considering emotional and cognitive profiles.

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Area of Science:

  • Neurology
  • Psychology
  • Medical Ethics

Background:

  • Advances in Alzheimer's disease (AD) treatments and biomarkers necessitate early diagnosis and risk estimation.
  • Autonomous decisions regarding AD risk are complex and require alignment with individual needs.
  • The PreTAD study investigates attitudes towards dementia risk estimation among relatives and patients with subjective cognitive decline.

Purpose of the Study:

  • To evaluate and compare attitudes on dementia risk estimation.
  • To improve counseling for preclinical predictive AD diagnostics.
  • To understand the influence of psychosocial factors on dementia risk perception.

Main Methods:

  • The PreTAD study assessed risk perception, attitudes, and psychosocial factors (loneliness, resilience, anxiety, depression).
  • Participants' perceived high general dementia risk and personal 10-year dementia risk were evaluated.
  • Data were collected from 390 participants across Germany, Switzerland, and Spain.

Main Results:

  • 70% of participants perceived their personal dementia risk as over 10%.
  • Higher personal risk perception correlated with greater perceived impact of biomarkers and clinical trials.
  • Perceived high general risk was linked to income, belief in lifestyle changes, and preference for test accuracy.

Conclusions:

  • Risk perception for Alzheimer's disease is highly individual and influences the estimation process.
  • Psychosocial factors showed limited impact on the decision to pursue risk estimation in hypothetical scenarios.
  • Personalized counseling considering emotional and cognitive profiles is essential for informed decision-making in preclinical AD diagnostics.