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Clinical Manifestations.

Jianwei Ge1, Yi Ling2, Benyan Luo3

  • 1First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Transcranial focused ultrasound (tFUS) shows promise for Alzheimer's disease (AD) by improving cognitive function and enhancing brain network connectivity. This non-invasive therapy may offer a new strategy for managing AD symptoms and slowing disease progression.

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Area of Science:

  • Neuroscience
  • Neuromodulation
  • Medical Imaging

Background:

  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder with limited treatment options.
  • Non-invasive neuromodulation techniques are gaining interest for AD management.
  • Transcranial focused ultrasound (tFUS) shows potential for modulating neural activity and enhancing neuroplasticity.

Purpose of the Study:

  • To evaluate the efficacy of tFUS in treating Alzheimer's disease patients.
  • To assess the impact of tFUS on cognitive function and brain network connectivity in AD.

Main Methods:

  • Two-week continuous tFUS treatment in AD patients.
  • Neuropsychological assessments (MMSE, MOCA).
  • Resting-state EEG, fMRI, graph theory, and edge analysis to evaluate brain connectivity and function.

Main Results:

  • Significant improvements in MMSE and MOCA scores observed after tFUS treatment.
  • Enhanced intra-network connectivity within the default mode network (DMN) and increased rich-club coefficient.
  • Reduced delta band power spectral density in the frontal region via resting-state EEG.

Conclusions:

  • tFUS stimulation shows potential for improving cognitive impairment in AD patients.
  • tFUS enhances DMN connectivity and functionality, potentially slowing disease progression.
  • tFUS offers a non-invasive therapeutic strategy for managing cognitive decline in AD.