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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Dan Liu1, Valentina Talevi2, Juliana F Tavares3

  • 1Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Epigenetic signatures in blood are linked to hippocampal volume differences and atrophy. Healthy diets may influence these methylation patterns, offering potential targets for brain health.

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Area of Science:

  • Neuroscience
  • Epigenetics
  • Aging Research

Background:

  • The hippocampus is vital for memory and shows left-right volume differences (LHCV, RHCV) and asymmetry.
  • The molecular basis for these hippocampal variations in the general population is not well understood.

Purpose of the Study:

  • To identify blood-based DNA methylation signatures associated with hippocampal volume and asymmetry.
  • To explore the molecular mechanisms and dietary influences on these associations.

Main Methods:

  • A meta-analysis of epigenome-wide association studies (EWAS) from six cohorts (8,156 individuals).
  • Integrative cross-omics analyses (genetics, methylation, gene expression) in the Rhineland Study.
  • Evaluation of dietary patterns' impact on methylation and longitudinal hippocampal changes.

Main Results:

  • Convergent methylation signatures for LHCV, RHCV, and asymmetry involved neuronal development pathways.
  • Identified CpG/DMR-gene expression pairs linked to immune and synaptic functions, explaining over 10% of hippocampal atrophy variation.
  • Found sex-specific differences in methylation associated with asymmetry and a link between healthy diets and methylation signatures.

Conclusions:

  • Blood methylation signatures may serve as biomarkers or therapeutic targets for hippocampal atrophy.
  • Modifiable dietary patterns significantly influence methylation and hippocampal health.