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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Anna S Lorenz1, Aditi Sathe2, Yisu Yang3

  • 1Vanderbilt Memory and Alzheimer's Center, Nashville, TN, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

This study reveals that white matter (WM) microstructure in older adults is heritable and linked to Alzheimer's Disease (AD) risk factors. Genetic analysis identified specific genes influencing WM integrity, offering new insights into AD mechanisms and potential therapeutic targets.

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Area of Science:

  • Neurogenetics
  • Neuroimaging
  • Aging Research

Background:

  • Limbic white matter (WM) abnormalities are common in Alzheimer's Disease (AD), but the biological basis is not fully understood.
  • Investigating genetic contributions to WM microstructure is crucial for understanding AD pathogenesis.

Purpose of the Study:

  • To conduct a large-scale genetic analysis of WM microstructure in older adults.
  • To identify genetic factors associated with WM integrity and their relationship to AD and cognitive decline.

Main Methods:

  • Utilized advanced diffusion MRI metrics (FAFWcorr, AxDFWcorr, MDFWcorr, RDFWcorr) to assess WM microstructure in seven limbic tracts.
  • Employed SNP-heritability estimation, genome-wide association studies (GWAS), and post-GWAS analyses on harmonized data from 2,614 older adults.
  • Integrated bulk RNA-seq brain data to link gene expression with cognition and AD pathologies.

Main Results:

  • Demonstrated significant heritability of WM microstructure (16 of 35 metrics, 0.26-0.60).
  • Identified genome-wide significant associations for specific genetic variants (SNPs) with WM microstructure metrics in fornix, ILF, STG, and cingulum.
  • Discovered that gene expression of RORA, FAM107, and KC6 is linked to cognitive decline and AD, while SERPINA12 is associated with type 2 diabetes and atherosclerosis.

Conclusions:

  • Genetic factors influencing cognition, vascular health, and inflammation contribute to WM microstructure changes in aging and AD.
  • Findings highlight potential molecular mechanisms in AD and suggest therapeutic targets related to vascular and metabolic health.
  • Opens new research avenues for understanding AD's molecular basis and developing interventions.