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Clinical Manifestations.

Melanie J Miller1, Naomi Saito2, Catherine C Conti1

  • 1Northern California Institute for Research and Education (NCIRE), San Francisco, CA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

A novel digital approach successfully recruited and screened older adults, including those with Mild Cognitive Impairment (MCI), for Alzheimer's Disease (AD) observational studies. Remote assessments effectively identified individuals with potential cognitive impairment for further clinical evaluation.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Digital Health

Background:

  • Scalable recruitment methods are crucial for Alzheimer's Disease (AD) observational studies and clinical trials, particularly for older adults with Mild Cognitive Impairment (MCI).
  • Traditional recruitment strategies often face challenges in efficiently reaching and enrolling this specific demographic.
  • A novel digital approach was evaluated for its feasibility in recruiting and screening participants for the Alzheimer's Disease Neuroimaging Initiative (ADNI4).

Purpose of the Study:

  • To assess the feasibility of a novel digital strategy for recruiting and screening older adults for AD research.
  • To determine if remote, unsupervised digital assessments can effectively identify individuals with possible cognitive impairment.
  • To adapt digital recruitment and assessment methods for broader application in AD research.

Main Methods:

  • Utilized targeted digital advertising to direct older adults near ADNI sites to a recruitment website.
  • Participants completed remote, unsupervised digital surveys and the Novoic Storyteller speech-based cognitive test.
  • Results from digital assessments prioritized individuals with potential MCI or dementia for in-clinic screening at ADNI sites.

Main Results:

  • 8103 participants enrolled in the Digital Cohort; 26% had ADNI exclusions.
  • 693 individuals were invited for referral, 313 accepted, and 54 were screened at ADNI sites.
  • Remote assessments (ECog12, Storyteller) correlated with cognitive impairment (CDR global >0), indicating potential for enrichment.

Conclusions:

  • Tailored digital advertising and remote, unsupervised assessments are feasible for recruiting and evaluating older adults, including those with possible cognitive impairment.
  • Remote assessments can effectively enrich study cohorts for individuals with cognitive impairment.
  • This digital approach is adaptable for recruitment and longitudinal assessment in other AD studies and trials.