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Metabolic profiling revealed alterations associated with sedentary work in bus drivers
Dafeng Lin1,2,3, Shaofan Weng4, Dianpeng Wang5
1Occupational Hazard Assessment Department, Shenzhen Prevention and Treatment Center for Occupational Diseases, Shenzhen, 518020, China. david1385@foxmail.com.
Professional bus drivers exhibit significant metabolic alterations due to prolonged sedentary work. This occupational sedentary behavior is linked to changes in amino acid metabolism and higher triglyceride levels, impacting public health.
Area of Science:
- Occupational Health
- Metabolomics
- Public Health
Background:
- Sedentary workplace behavior is a growing public health issue.
- Bus drivers face prolonged sitting, classifying them as a high-risk occupational group.
Purpose of the Study:
- To investigate metabolic differences in bus drivers compared to active controls.
- To identify metabolic alterations linked to occupational sedentary behavior.
Main Methods:
- Compared 60 bus drivers with 60 matched sanitation workers.
- Utilized ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for serum metabolomic profiling.
- Collected demographic and biochemical data, including triglyceride levels.
Main Results:
- Identified 57 differential metabolites between bus drivers and controls (52 up-regulated, 5 down-regulated).
- Observed significant pathway perturbations in amino acid biosynthesis and metabolism.
- Found higher triglyceride levels in bus drivers (P=0.037).
Conclusions:
- Prolonged occupational sedentary behavior in bus drivers is associated with distinct metabolic signatures.
- Findings suggest mechanisms linking sedentary work to adverse health outcomes.
- Highlights the need for interventions targeting sedentary occupations.
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