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Related Concept Videos

Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

275
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
275
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

430
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
430
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

285
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
285
Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

1.1K
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
1.1K
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

317
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
317
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364

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Related Experiment Video

Updated: Jan 7, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
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Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

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Pyoderma gangrenosum associated with granulomatosis with polyangiitis: a case report.

Marwa Ben Brahim1, Sirine Abdellatif2, Asma Ben Mabrouk1

  • 1Department of Internal Medicine, Taher Sfar University Hospital, University of Monastir, Mahdia, Tunisia.

Journal of Medical Case Reports
|December 24, 2025
PubMed
Summary

This case study highlights a rare association between granulomatosis with polyangiitis and pyoderma gangrenosum in a young patient. Early diagnosis and prompt treatment are crucial for managing this challenging condition.

Keywords:
AssociationCase reportGranulomatosis with polyangiitisPyoderma gangrenosum

Related Experiment Videos

Last Updated: Jan 7, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

10.8K

Area of Science:

  • Immunology
  • Dermatology
  • Rheumatology

Background:

  • Pyoderma gangrenosum is a neutrophilic dermatosis with unclear pathogenesis.
  • The co-occurrence of pyoderma gangrenosum and granulomatosis with polyangiitis is infrequently documented.
  • This report details a case of pyoderma gangrenosum in a patient with granulomatosis with polyangiitis.

Purpose of the Study:

  • To present a rare case of pyoderma gangrenosum in a patient with granulomatosis with polyangiitis.
  • To discuss the diagnostic challenges and management of this dual condition.
  • To emphasize the importance of histopathological examination in differentiating similar ulcerative lesions.

Main Methods:

  • A 26-year-old male patient with granulomatosis with polyangiitis presented with nasal symptoms and later developed a significant leg ulcer.
  • Diagnostic workup included nasal endoscopy, biopsies, and CT scans.
  • Treatment involved corticosteroids and cyclophosphamide.

Main Results:

  • The patient was initially diagnosed with localized granulomatosis with polyangiitis and treated.
  • Three years later, he presented with severe nasal destruction and a large necrotic leg ulcer.
  • Histopathology confirmed pyoderma gangrenosum, leading to a diagnosis of co-existing granulomatosis with polyangiitis and pyoderma gangrenosum.
  • The patient showed prompt recovery after adjusted immunosuppressive therapy.

Conclusions:

  • Skin manifestations are common in granulomatosis with polyangiitis, but classic pyoderma gangrenosum association is rare.
  • Distinguishing pyoderma gangrenosum from pyoderma gangrenosum-like ulcers in GPA is clinically challenging.
  • Histopathology is essential for accurate diagnosis and guiding treatment decisions.