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Clinical Manifestations.

Sophie Alderman1, George Stothart1, Martha Hickey2

  • 1University of Bath, Bath, United Kingdom.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Nocturnal vasomotor symptoms (VMS) in menopausal women may be a risk factor for Alzheimer's disease (AD). This study investigates the link between VMS, AD biomarkers, and cognitive decline in women.

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Area of Science:

  • Neuroscience
  • Women's Health
  • Gerontology

Background:

  • Alzheimer's disease (AD) disproportionately affects women, with female sex being a significant risk factor.
  • While longer life expectancy was initially considered, increased AD risk in women persists even after accounting for survival rates.
  • Recent research links nocturnal vasomotor symptoms (VMS), a menopausal symptom, to AD biomarkers.

Purpose of the Study:

  • To investigate the mechanisms connecting nocturnal VMS and Alzheimer's disease pathology.
  • To determine if severe VMS is associated with increased AD pathology and altered sleep patterns.
  • To assess the relationship between VMS severity and cognitive function in menopausal women.

Main Methods:

  • Recruiting 150 perimenopausal and postmenopausal women experiencing VMS.
  • Classifying menopausal status using Stages of Reproductive Aging Workshop (STRAW + 10).
  • Measuring VMS severity and interference using Core Outcomes in Menopause (COMMA) measurements.
  • Utilizing electroencephalography (EEG) for 7 nights to monitor sleep and VMS.
  • Assessing cognitive function through a battery of tests and analyzing plasma biomarkers.

Main Results:

  • The study is designed to collect data on VMS, sleep macroarchitecture, cognitive function, and AD biomarkers.
  • Results are anticipated following the study's commencement in October 2025.

Conclusions:

  • This research aims to establish nocturnal VMS as a potential female-specific risk factor for AD.
  • Identifying VMS as a midlife risk factor could lead to early interventions to preserve brain health.
  • Findings may help reduce the incidence and progression of cognitive decline in women.