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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Sophie A Froud1, Benjamin A Levett1, Lucy B Core1

  • 1Dementia Research Centre, UCL Queen Square Institute of Neurology, London, London, United Kingdom.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Understanding speech in noisy environments is challenging for individuals with Alzheimer's disease (AD) and certain primary progressive aphasia (PPA) syndromes, indicating distinct auditory brain dysfunction. This research highlights separable speech-in-noise processing deficits in dementia.

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Area of Science:

  • Neuroscience
  • Audiology
  • Cognitive Science

Background:

  • Speech-in-noise perception is a complex neural process vulnerable to neurodegeneration.
  • Understanding how dementia syndromes affect speech-in-noise processing and its neural basis is crucial.
  • Previous research has not clearly defined these effects across different dementia types.

Purpose of the Study:

  • To investigate speech-in-noise processing deficits in Alzheimer's disease (AD) and primary progressive aphasia (PPA) syndromes.
  • To determine the relationship between hearing loss and impaired speech-in-noise perception in dementia.
  • To identify the brain structures associated with difficulties in understanding speech in noise.

Main Methods:

  • Administered a Digit Triplets test with adaptive signal-to-noise ratio (SNR) adjustment.
  • Assessed peripheral hearing, general cognition, and performed volumetric brain MRI with voxel-based morphometry (VBM).
  • Included 48 dementia patients (AD, lvPPA, svPPA, nfvPPA) and 22 healthy controls.

Main Results:

  • AD, lvPPA, and nfvPPA groups showed significantly worse speech-in-noise perception (higher SNR thresholds) than controls.
  • The logopenic variant of PPA (lvPPA) exhibited the most pronounced impairment.
  • Voxel-based morphometry identified auditory cortical correlates of speech-in-noise performance.

Conclusions:

  • Alzheimer's disease and PPA syndromes present distinct patterns of speech-in-noise impairment.
  • These deficits reflect underlying auditory brain dysfunction specific to dementia syndromes.
  • Speech-in-noise testing can help characterize neurodegenerative processes affecting auditory processing.