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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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Clinical Manifestations.

See Ann Soo1, Jermyn Z See1, Nav Vij1

  • 1Neurowyzr Pte Ltd, Singapore, Singapore, Singapore.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

The Digital Brain Function Screen (DBFS) demonstrates strong construct validity and high test-retest reliability compared to the MoCA for detecting mild cognitive impairment. This establishes DBFS as a dependable tool for monitoring cognitive decline.

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Area of Science:

  • Neuroscience
  • Medical Technology
  • Cognitive Science

Background:

  • The Digital Brain Function Screen (DBFS) is a digital tool for early detection and monitoring of Mild Cognitive Impairment (MCI).
  • While comparable to the MoCA, DBFS lacked formal validation of its construct validity and test-retest reliability.
  • This study aimed to establish these psychometric properties for DBFS.

Purpose of the Study:

  • To evaluate the construct validity of the DBFS against the MoCA.
  • To assess the test-retest reliability of the DBFS.
  • To confirm DBFS as a valid and reliable tool for cognitive assessment.

Main Methods:

  • 157 individuals (aged 10-81) underwent DBFS and MoCA assessments.
  • 36 participants completed a second DBFS assessment after a median interval of 305 days.
  • Construct validity and test-retest reliability were analyzed using partial Spearman's rank correlations, controlling for age, sex, and education.

Main Results:

  • DBFS total scores significantly correlated with MoCA total scores (p < 0.001).
  • Strong positive correlations were found between corresponding DBFS and MoCA domains (p < 0.05), indicating good construct validity.
  • Test-retest reliability for DBFS was high, with Spearman's ρ = 0.65 (p < 0.001).

Conclusions:

  • DBFS effectively measures intended cognitive constructs and shows high reliability over time.
  • The findings validate DBFS as a practical, scalable, and efficient tool for detecting and monitoring early cognitive impairment.
  • DBFS is suitable for deployment in diverse healthcare settings for cognitive screening.