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Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
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Basic Science and Pathogenesis.

Tatiana M Foroud1,2, Kelley M Faber1,2, Kaci Lacy1,2

  • 1National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD), Indianapolis, IN, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Researchers can advance Alzheimer's Disease and Related Dementias (ADRD) research by sharing data from biological samples. The National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) facilitates this through agreements and data sharing practices.

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Area of Science:

  • Neuroscience
  • Biomedical Research
  • Data Science

Background:

  • Advancing Alzheimer's Disease and Related Dementias (ADRD) research requires accessible biological samples and shared data.
  • Preventing redundant experiments and enabling advanced studies depend on effective data sharing from valuable research samples.

Purpose of the Study:

  • To outline the National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) commitment to broad data sharing.
  • To detail NCRAD's established standard operating procedures and best practices for biorepositories to support data sharing.

Main Methods:

  • Implementing material transfer agreements that mandate data sharing with approved resources.
  • Distributing blinded samples, with unblinding contingent upon raw data return to a data sharing resource.
  • Conducting pre-distribution calls to discuss data requirements and formats.
  • Developing web-based catalogs for sample selection and data download, accessible after signing data use agreements.

Main Results:

  • NCRAD employs three primary data sharing techniques: material transfer agreements, blinded sample distribution, and pre-distribution researcher consultations.
  • NCRAD has developed 13 web-based catalogs for sample selection and data analysis, enhancing accessibility.
  • All data access and sample selection through NCRAD catalogs require a signed data use agreement.

Conclusions:

  • NCRAD's dedication to open data sharing from biological samples significantly accelerates progress in ADRD research.
  • NCRAD's practices serve as a model for other biorepositories aiming to promote widespread data sharing in biomedical research.