Related Experiment Video
Updated: Jan 7, 2026

In vitro Assessment of Aortic Regurgitation Using Four-Dimensional Flow Magnetic Resonance Imaging
Published on: February 25, 2022
Phase contrast CMR in the descending aorta as a supportive reference for severe aortic regurgitation
Frida Truedsson1,2,3, Sinsia A Gao4,5, Christian L Polte4,5,6
1Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. frida.truedsson@regionhalland.se.
Abstract:
Accurate grading of aortic regurgitation (AR) severity is crucial for treatment decisions. This study aimed to determine whether phase contrast cardiac magnetic resonance (PC-CMR) in the descending aorta can be used as a supporting reference for grading of the AR severity in patients with chronic AR. PC-CMR was performed both in the ascending and descending aorta of 191 AR-patients. Regurgitation thresholds in the descending aorta for hemodynamically significant AR [regurgitation volume (RVol)DA and fraction (RF)DA] were determined in 41 well-controlled patients and then validated in a cohort surveyed for AR in our clinic. Myerson's outcome-based thresholds (RVol > 42 mL, RF > 33%) served as reference. For comparison, holodiastolic flow reversal (HFR) was determined. Regurgitation measurements in the descending and ascending aorta were strongly correlated (RVol: R ≥ 0.92; RF: R ≥ 0.85; p < 0.001). Diagnostic performance of RVolDA>17 mL and RFDA>23% was high (sensitivity: 92%, 83%; specificity: 95%, 93%) and more patients with significant AR were identified using these PC-MRI based thresholds [RVolDA>17mL (13%) and RFDA>23% (15%)] than with HFR alone. PC-CMR in the descending aorta has the potential to reliably grade AR severity in patients with chronic AR and thereby may serve as a supportive reference in the decision-making regarding optimal timing of intervention.
More Related Videos
08:31A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
Published on: October 16, 2021
11:50High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
Published on: July 9, 2010
Related Concept Videos
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Mitral Regurgitation II: Clinical Features and Diagnostic Tests
Aortic Regurgitation I: Introduction
Mitral Stenosis II: Clinical features and Diagnostic Tests
Mitral Regurgitation I: Introduction
Aortic Regurgitation III: Medical Management