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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Mengjie Wang1

  • 1Huashan Hospital, Fudan University, shanghai, shanghai, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Phosphorylated tau pathology drives synaptic damage in Alzheimer's disease (AD). Plasma p-tau217 shows promise as a biomarker for early AD synaptic injury screening.

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Area of Science:

  • Neuroscience
  • Biomarker Discovery
  • Alzheimer's Disease Research

Background:

  • Synaptic damage is a key factor in Alzheimer's disease (AD) cognitive decline.
  • Synaptic vesicle protein 2A (SV2A) serves as a biomarker for synaptic injury in AD.
  • Investigating the link between synaptic damage and tau pathology is crucial for understanding AD progression.

Purpose of the Study:

  • To explore the mechanisms connecting synaptic damage and tau pathology in Alzheimer's disease.
  • To assess the role of plasma tau biomarkers in relation to synaptic integrity.
  • To identify potential plasma biomarkers for early detection of AD-related synaptic injury.

Main Methods:

  • Analysis of 239 subjects from the Huashan cohort using SV2A PET scans (18F-SynVesT-1).
  • Comparison of synaptic and plasma tau biomarkers between amyloid PET-negative and positive groups using t-tests.
  • General Linear Model (GLM) and mediation analyses adjusted for age, sex, and education.

Main Results:

  • Amyloid PET-positive individuals exhibited significantly increased synaptic injury.
  • Plasma p-tau217 demonstrated a significant association with synaptic biomarkers.
  • Plasma p-tau217 effects on SV2A PET hippocampal SUVR were mediated by FBP Centiloid and MK6240 MetaTEM-ROI; effects on CSF GAP43 were mediated by CSF Aβ42 and CSF p-tau181.

Conclusions:

  • Phosphorylated tau pathology is confirmed as a critical pathway leading to synaptic damage.
  • Plasma p-tau217 is strongly linked to both peripheral and central synaptic changes.
  • Plasma p-tau217 holds potential as a biomarker for early screening and prediction of synaptic injury in AD.