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Published on: September 20, 2018
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Clinical Manifestations.
Benjamin S Zide1, Jessa Burling2, David H Adamowicz1,3,4
1Brigham and Women's Hospital, Boston, MA, USA.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
Summary
Greater wisdom in older adults was linked to less amyloid buildup in the brain, a key marker for preclinical Alzheimer's disease (AD). This suggests wisdom may be a potential indicator for early AD detection.
Area of Science:
- Neuroscience
- Gerontology
- Psychology
Background:
- Wisdom, a complex cognitive and socioemotional capacity, influences daily decision-making.
- It represents superior mental functioning, not necessarily tied to age, IQ, or education.
- Its relationship with preclinical Alzheimer's disease (AD) biomarkers is not well understood.
Purpose of the Study:
- To investigate the association between wisdom and its subdomains with demographic and clinical variables.
- To determine the relationship between wisdom and neuroimaging biomarkers of AD in cognitively unimpaired older adults.
Main Methods:
- 106 cognitively unimpaired older adults from the Harvard Aging Brain Study were assessed.
- Measures included self-reported wisdom (SD-Wise Scale), IQ, cognition (CFI, PACC), and depression (GDS).
- Amyloid-beta (Aβ) burden was measured using PiB-PET scans in 83 participants.
Main Results:
- Higher wisdom correlated with female sex and lower depression scores.
- Greater total wisdom was associated with lower cortical amyloid-beta (PiB-SUVr) burden.
- Specific wisdom domains (decisiveness, self-reflection, social advising) were linked to lower Aβ burden.
Conclusions:
- Wisdom was not associated with education, IQ, or cognitive performance in this sample.
- Wisdom, particularly its components like decisiveness and self-reflection, may be sensitive to Aβ pathology.
- Wisdom could represent a measurable, potentially unrecognized, sign of preclinical Alzheimer's disease.
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