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Clinical Manifestations.

Benjamin S Zide1, Jessa Burling2, David H Adamowicz1,3,4

  • 1Brigham and Women's Hospital, Boston, MA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Greater wisdom in older adults was linked to less amyloid buildup in the brain, a key marker for preclinical Alzheimer's disease (AD). This suggests wisdom may be a potential indicator for early AD detection.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Psychology

Background:

  • Wisdom, a complex cognitive and socioemotional capacity, influences daily decision-making.
  • It represents superior mental functioning, not necessarily tied to age, IQ, or education.
  • Its relationship with preclinical Alzheimer's disease (AD) biomarkers is not well understood.

Purpose of the Study:

  • To investigate the association between wisdom and its subdomains with demographic and clinical variables.
  • To determine the relationship between wisdom and neuroimaging biomarkers of AD in cognitively unimpaired older adults.

Main Methods:

  • 106 cognitively unimpaired older adults from the Harvard Aging Brain Study were assessed.
  • Measures included self-reported wisdom (SD-Wise Scale), IQ, cognition (CFI, PACC), and depression (GDS).
  • Amyloid-beta (Aβ) burden was measured using PiB-PET scans in 83 participants.

Main Results:

  • Higher wisdom correlated with female sex and lower depression scores.
  • Greater total wisdom was associated with lower cortical amyloid-beta (PiB-SUVr) burden.
  • Specific wisdom domains (decisiveness, self-reflection, social advising) were linked to lower Aβ burden.

Conclusions:

  • Wisdom was not associated with education, IQ, or cognitive performance in this sample.
  • Wisdom, particularly its components like decisiveness and self-reflection, may be sensitive to Aβ pathology.
  • Wisdom could represent a measurable, potentially unrecognized, sign of preclinical Alzheimer's disease.