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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
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Clinical Manifestations.
Avinash Chandra1, Sheena Waters1, Yue Liu1
1Queen Mary University of London, London, Greater London, United Kingdom.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
Summary
Vestibular dysfunction, indicated by dizziness, is linked to early Alzheimer's disease markers like tau pathology and hippocampal atrophy in cognitively normal individuals. Further research is needed to confirm the causal relationship and its implications for neurodegeneration.
Area of Science:
- Neuroscience
- Neurology
- Gerontology
Background:
- Vestibular system impairments are associated with increased dementia risk and cognitive decline.
- Subjective dizziness is a common symptom of vestibular dysfunction, but its neuropathological link to cognition is unclear.
Purpose of the Study:
- To investigate the association between self-reported dizziness and early neurodegenerative markers.
- To explore the neuropathological underpinnings of how vestibular dysfunction may impact cognition.
Main Methods:
- Analysis of data from 1677 participants in the Alzheimer's Disease Neuroimaging Initiative.
- Assessment of self-reported dizziness and other vestibular symptoms.
- Examination of associations with cerebrospinal fluid (CSF) Alzheimer's disease (AD) markers, MRI/PET scans, cognitive performance, and biomarkers.
Main Results:
- In cognitively normal subjects, dizziness with other vestibular symptoms correlated with higher CSF t-tau levels.
- Self-reported dizziness in cognitively normal individuals was associated with reduced hippocampal volume.
- These associations showed trends in combined groups of cognitively normal, mild cognitive impairment (MCI), and AD cases.
Conclusions:
- The study suggests potential early degenerative markers linked to vestibular dysfunction, specifically tau pathology and hippocampal atrophy.
- The directionality of the relationship between vestibular damage and neurodegeneration requires further investigation.
- Evaluating vestibular dysfunction may be important in assessing early-stage neurodegenerative processes.
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