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Basic Science and Pathogenesis.

Shyam Tamizharasu1, David Garcia1, Naomi Saito2

  • 1University of California, Davis, Sacramento, CA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
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Summary
This summary is machine-generated.

Mineralized blood vessels (MBV) are common in Alzheimer disease (AD). This study found MBV prevalence varied by brain region, but not significantly between Hispanic and non-Hispanic White individuals with AD.

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Area of Science:

  • Neuropathology
  • Neurodegenerative Diseases
  • Vascular Biology

Background:

  • Mineralized blood vessels (MBV) contribute to vascular stiffening and are prevalent in neurodegenerative disorders like Alzheimer disease (AD).
  • Limited research exists on MBV in postmortem studies, especially in non-Hispanic White populations.

Purpose of the Study:

  • To investigate the prevalence and regional distribution of MBV in the brains of Hispanic and non-Hispanic White individuals with pathologically confirmed AD.
  • To address the gap in neuropathological research concerning MBV in diverse populations.

Main Methods:

  • Examined postmortem brain tissue from Hispanic (n=92) and non-Hispanic White (n=184) decedents with confirmed AD.
  • Assessed MBV presence in the posterior hippocampus, putamen, and globus pallidus using hematoxylin and eosin-stained sections.

Main Results:

  • MBV prevalence was highest in the globus pallidus (59.0%), followed by the posterior hippocampus (28.6%), and putamen (14.8%).
  • MBV burden significantly differed across brain regions (p < .001 for all comparisons).
  • No significant differences in MBV presence were found between Hispanic and non-Hispanic White individuals with AD (p = .63).

Conclusions:

  • MBV exhibit region-specific patterns in Alzheimer disease brains.
  • This study contributes to understanding MBV as an understudied vascular neuropathology in AD.
  • Further research is needed to elucidate the role of MBV in AD pathogenesis.