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Clinical Manifestations.

Dawn Mechanic-Hamilton1, Valerie Humphreys2, Danielle Hing2

  • 1Penn Alzheimer's Disease Research Center, University of Pennsylvania, Philadelphia, PA, USA.

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|December 25, 2025
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Summary
This summary is machine-generated.

This pilot study demonstrates the mobile cognitive app performance platform (mCAPP) is usable for remote cognitive assessment in patients with Mild Cognitive Impairment (MCI) or Alzheimer's disease (AD) undergoing anti-amyloid therapies (AATs). Findings support mCAPP's potential for tracking treatment effects.

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Area of Science:

  • Neuroscience
  • Digital Health
  • Clinical Trials

Background:

  • Effective cognitive assessment is crucial for monitoring neurodegenerative diseases and treatment responses.
  • The advent of anti-amyloid therapies (AATs) necessitates reliable methods for tracking treatment benefits and risks.
  • Remote, app-based assessments offer a scalable solution for cognitive monitoring.

Purpose of the Study:

  • To evaluate the feasibility and usability of the mobile cognitive app performance platform (mCAPP) for at-home cognitive assessment.
  • To collect remote cognitive performance data in patients with Mild Cognitive Impairment (MCI) or mild Alzheimer's disease (AD) undergoing AAT.
  • To assess the initial reliability and validity of mCAPP compared to traditional neuropsychological tests.

Main Methods:

  • A pilot study involving 11 participants with MCI or mild AD undergoing AAT.
  • Participants used the gamified mCAPP tasks both in-clinic and at home for up to three months.
  • Data collected included mCAPP usage, usability ratings, and comparisons with paper-and-pencil neuropsychological tests.

Main Results:

  • Participants consistently engaged with mCAPP at home (1-3 sessions/week) for up to 3 months.
  • mCAPP demonstrated good usability (7.1/9 rating) and task difficulty was perceived as appropriate by most users.
  • All mCAPP tasks showed performance differences between low and high cognitive load conditions, indicating sensitivity to cognitive load.

Conclusions:

  • The mobile cognitive app performance platform (mCAPP) is a usable tool for in-clinic and at-home cognitive assessment in patients receiving AAT.
  • Initial results suggest mCAPP has reliability and validity for assessing cognitive performance in this population.
  • Future research will focus on longitudinal data analysis and practice effects of mCAPP.