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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Ping Che1, Nan Zhang2

  • 1Tianjin Medical University General Hospital, Jin Tian, Jin Tian, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Plasma phosphorylated tau (p-tau217) is an optimal Alzheimer's disease biomarker. This study established reference intervals in Chinese individuals, showing p-tau217 accurately diagnoses AD, even in early stages.

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Area of Science:

  • Neuroscience
  • Biomarker Research
  • Clinical Diagnostics

Background:

  • Plasma phosphorylated tau at threonine 217 (p-tau217) is an optimal biomarker for Alzheimer's disease (AD).
  • Establishing reference intervals and diagnostic value in Chinese populations is crucial for clinical application.

Purpose of the Study:

  • To establish the reference interval of plasma p-tau217 in Chinese individuals.
  • To evaluate the diagnostic value of plasma p-tau217 in symptomatic AD and other neurodegenerative diseases.

Main Methods:

  • Recruited 150 cognitively unimpaired (CU) individuals, 60 AD dementia patients, 30 mild cognitive impairment (MCI) due to AD patients, 40 frontotemporal lobar degeneration (FTLD) patients, and 70 subcortical ischemic vascular dementia (SIVD) patients.
  • Measured plasma p-tau217, total tau, amyloid-beta (Aβ)42, and Aβ40 concentrations using a single-molecule array assay.

Main Results:

  • Plasma p-tau217 demonstrated high diagnostic accuracy for AD compared to CU, FTLD, and SIVD patients (AUCs = 0.983, 0.936, 0.892, respectively).
  • Plasma p-tau217 also effectively discriminated MCI due to AD from CU individuals (AUC = 0.943).
  • Plasma p-tau217 levels showed a negative correlation with memory function in symptomatic AD patients.

Conclusions:

  • Plasma p-tau217 exhibits exceptional diagnostic accuracy for Alzheimer's disease in the Chinese population.
  • This biomarker is effective even in the early stages of AD, offering potential for early diagnosis and intervention.