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Clinical Manifestations.

Tamlyn J Watermeyer1,2,3, Joe Butler4,5, Samuel O Danso6,7

  • 1Edinburgh Dementia Prevention, Centre for Clinical Brain Sciences, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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PubMed
Summary
This summary is machine-generated.

A new digital visual short-term memory binding (dVSTMB) task shows promise for detecting early Alzheimer's disease (AD) in adults with Down syndrome (DS). The dVSTMB is feasible and acceptable, with some participants meeting AD-indicative criteria.

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Area of Science:

  • Neuroscience
  • Psychology
  • Genetics

Background:

  • Adults with Down syndrome (DS) have a significantly higher risk of early-onset Alzheimer's disease (AD).
  • Current neuropsychological tools lack sensitivity for early AD detection in the DS population, hindering research participation.
  • Conjunctive memory binding, assessed by the visual short-term memory binding (VSTMB) task, is an early indicator of AD pathology.

Purpose of the Study:

  • To evaluate the feasibility, acceptability, and discriminative ability of a novel digital VSTMB (dVSTMB) adapted for individuals with DS.
  • To assess the dVSTMB's potential as a sensitive tool for early AD detection in the DS population.

Main Methods:

  • Seventeen participants with DS completed the dVSTMB and the Horizon 21 Alzheimer's disease (H21AD) battery.
  • A Bayesian paired-samples t-test compared performance between dVSTMB's Shape-Only and Colour-Binding conditions.
  • Participants were classified as "weak" or "strong" binders based on binding-cost score (BCS) criteria.

Main Results:

  • The dVSTMB had an 82.4% completion rate; non-completion was due to instruction difficulty, not dropouts.
  • Non-speaking participants successfully completed the dVSTMB, unlike some H21-AD items.
  • High enjoyment ratings (M=6.33) were reported for the dVSTMB; participants performed better in the Shape-Only condition (BF+0=44.28).

Conclusions:

  • The dVSTMB demonstrates initial feasibility and acceptability for individuals with DS.
  • Some participants met BCS criteria suggestive of AD, indicating potential for AD screening in this population.
  • Further monitoring of task instructions and expansion to other learning disability groups are planned.