Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular and bioinformatic mechanism of asiaticoside on macrophage-mediated keloid pathogenesis.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

Early prediction of immune checkpoint inhibitor-related pneumonitis in advanced non-small cell lung cancer based on primary tumor delta-radiomics features.

Frontiers in immunology·2026
Same author

Identification of QTLs Associated with Stem Breaking Strength and Development of InDel Markers in Soybean Using BSA-Seq.

Plants (Basel, Switzerland)·2026
Same author

Atomic Interfacial <i>N</i>-Bridging Locks <i>Z</i>-Scheme Charge Transfer in CsPbBr<sub>3</sub>@UiO-66-NH<sub>2</sub> Heterojunctions.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Discovery of a novel cinnamoyl piperazinyl alepterolic acid hybrid as a TrxR1 inhibitor for inducing ROS/ER stress-mediated apoptosis in breast cancer.

European journal of medicinal chemistry·2026
Same author

In Vivo Metabolic Profiling of Equisetum debile Roxb. in Rats Based on High-Resolution Mass Spectrometry.

Biomedical chromatography : BMC·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Correlates and predictors of self-efficacy among dementia caregivers: D-CARE findings.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

What should convince a clinician of disease modification in Alzheimer's disease clinical trials?

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Primary cilia-extracellular vesicle crosstalk in Alzheimer's disease: Emerging mechanisms and biomarker potential.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

Biomarkers.

Hui Zhao1, Wenting Song2, Haifeng Chen2

  • 1Department of Neurology, Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

The APOEε4 gene alters default mode network (DMN) functional gradients in Alzheimer's disease (AD) patients, particularly in the right temporal lobe. This disruption correlates with cognitive decline and may be influenced by AD biomarkers.

More Related Videos

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Related Experiment Videos

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Area of Science:

  • Neuroscience
  • Genetics
  • Medical Imaging

Background:

  • The APOEε4 allele is a significant risk factor for Alzheimer's disease (AD).
  • Functional connectivity gradients offer a novel way to analyze brain network organization.
  • Understanding how APOEε4 influences these gradients in AD is crucial.

Purpose of the Study:

  • To investigate the effect of the APOEε4 allele on default mode network (DMN) functional connectivity gradients in Alzheimer's disease.
  • To explore the correlation between DMN functional gradients and cognitive function in relation to APOEε4 status.
  • To examine the role of AD biomarkers in mediating the relationship between APOEε4 and DMN functional gradients.

Main Methods:

  • Recruited 271 subjects (healthy controls and AD patients, with and without APOEε4 carriers).
  • Utilized cognitive function testing, AD biomarker blood tests, and resting-state functional magnetic resonance imaging (rs-fMRI).
  • Employed two-factor ANOVA, correlation tests, and mediation analyses to assess relationships.

Main Results:

  • An interaction was found between APOEε4 presence and DMN functional gradients in the right temporal lobe.
  • In non-carriers, AD showed higher DMN gradients; in carriers, AD showed lower DMN gradients.
  • APOEε4 carriers with AD exhibited decreased DMN functional gradients, positively correlated with cognitive function, and were mediated by AD biomarkers.

Conclusions:

  • The APOEε4 gene significantly impacts DMN functional gradients in the right temporal lobe of AD patients.
  • APOEε4 carriers with AD experience greater functional network derangement, linked to cognitive deterioration.
  • AD biomarkers may influence DMN functional gradients, affecting resting-state functional connectivity in AD.