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Clinical Manifestations.

Ileana De Anda-Duran1, Phillip H Hwang2, Elizabeth Leverant3

  • 1Celia Scott Weatherhead Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

An abbreviated digital Trail Making Test-Part B effectively screens for mild cognitive impairment (MCI) by measuring time spent in targets, aiding early Alzheimer's disease detection.

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Medical Technology

Background:

  • Emerging monoclonal antibody treatments for Alzheimer's disease (AD) necessitate early identification of mild cognitive impairment (MCI).
  • Digital Trail Making Test-Part B (dTMT-B) novel metrics show promise in differentiating MCI from normal cognition (NC).

Purpose of the Study:

  • To assess the efficacy of an abbreviated dTMT-B in distinguishing MCI from NC.
  • To explore the relationship between abbreviated dTMT-B performance and traditional neuropsychological tests.

Main Methods:

  • Developed an abbreviated dTMT-B focusing on the initial half of the test.
  • Collected data from 58 memory clinic patients classified as MCI or NC.
  • Analyzed process metrics: hit duration, distance, and velocity.

Main Results:

  • MCI patients exhibited longer hit durations compared to NC patients (p < 0.004).
  • Longer hit duration correlated with poorer performance in attention, working memory, and episodic memory tests.
  • No significant differences were found for total distance or pen stroke velocity.

Conclusions:

  • An abbreviated digital Trail Making Test-Part B provides novel process-based metrics for cognitive assessment.
  • This abbreviated version offers a versatile tool for screening emergent cognitive impairment.