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Basic Science and Pathogenesis.

Pedro R Mena1, Andrew F Zaman1, Michael L Cuccaro2

  • 1University of Miami Miller School of Medicine, Miami, FL, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

The DAWN Study is building a diverse genetic resource for Alzheimer's disease (AD) research, aiming to improve understanding and treatment for all populations. This initiative collects extensive data from underrepresented groups to advance AD genetics.

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Area of Science:

  • Neuroscience
  • Genetics
  • Public Health

Background:

  • The DAWN Alzheimer's Research Study is an international initiative to enhance genetic diversity in Alzheimer's disease (AD) research.
  • It aims to create a comprehensive resource by collecting clinical, social, behavioral, environmental, genetic, and biomarker data from diverse populations.

Purpose of the Study:

  • To increase representation of African ancestry (Americans with African ancestry [AAA] and Indigenous Africans [IA]) and Latin Americans (LA) in AD studies.
  • To leverage comprehensive genetic variation for a better understanding and treatment of AD across all populations.

Main Methods:

  • Ascertainment of participants from clinical and community settings, covering a range of cognitive statuses (AD/dementia, AD Related Dementia, mild cognitive impairment, no cognitive impairment).
  • Standardized clinical protocol including history, neuropsychological, functional, neurobehavioral, and epidemiological assessments, harmonized with the Alzheimer's Disease Sequencing Project.
  • Rigorous quality control and data processing using decision tree algorithms and reviewer-based adjudication, adapted for US and African sites.

Main Results:

  • Over 5,000 participants (IA, AAA, LA) ascertained in the first two years, with detailed demographic and clinical data.
  • Participant demographics: IA (58% Female, mean age 74.5), AAA (81% Female, mean age 71.6), LA (76% Female, mean age 72.2).
  • Clinical diagnoses distribution varies across groups, with significant proportions in NCI, AD, and ADRD/MCI categories.

Conclusions:

  • The DAWN Study has successfully ascertained and processed over 5,000 participants, demonstrating productive progress.
  • This collaborative project is poised to accelerate the identification and understanding of genetic risk factors for Alzheimer's disease in diverse populations.