Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

3.3K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.3K
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

10.4K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Engineered multivalent VCAM1-Fc decoys remodel ECM mechanosensing to suppress H3K18la-driven epigenetic programs and stemness in recurrent glioblastoma.

Cancer letters·2026
Same author

Development of Glycosylated and Dimeric FAP-Targeted Radiotracers for Preclinical Evaluation in FAP-Positive Glioblastoma Models.

Journal of medicinal chemistry·2026
Same author

Microscale mechanical properties of brain tumor characterized by atomic force microscopy: implications for delineation of glioblastoma margin.

Journal of biomechanics·2026
Same author

Trait Architecture of Fruit-Panicle Economic Traits in <i>Idesia polycarpa</i> and Its Implications for Breeding.

Plants (Basel, Switzerland)·2026
Same author

Oat-β-glucan potentiates anti-PD-1 efficacy through Faecalibacterium prausnitzii-derived butyrate and indole-3-propionic acid.

Cell host & microbe·2026
Same author

Development and validation of a machine learning-based diagnostic system for 22 pediatric respiratory pathogens: a large-scale multicenter study.

NPJ digital medicine·2026

Related Experiment Video

Updated: Jan 7, 2026

A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics
08:42

A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics

Published on: September 19, 2016

9.2K

Targeting KAT8 alleviates vascular senescence by modulating the INHBA/TGF-β pathway.

Zhongxiao Lin1, Jianyu Xiong2, Fuyuan Zhang2

  • 1Laboratory for the Drug Discovery from Natural Resources and School of Pharmacy, Macau University of Science and Technology, Macau, China; Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, P.R. China.

Molecular Therapy : the Journal of the American Society of Gene Therapy
|December 25, 2025
PubMed
Summary

Lysine acetyltransferase 8 (KAT8) prevents vascular aging by maintaining endothelial cell function. Downregulation of KAT8 accelerates aging, while its enhancement protects against vascular senescence and related diseases.

Keywords:
ATAC-seqacetyltransferases KAT8miRNA-seqvascular senescence

More Related Videos

Retinal Explant of the Adult Mouse Retina as an Ex Vivo Model for Studying Retinal Neurovascular Diseases
06:51

Retinal Explant of the Adult Mouse Retina as an Ex Vivo Model for Studying Retinal Neurovascular Diseases

Published on: December 9, 2022

5.1K
TGF-&#946;-mediated Endothelial to Mesenchymal Transition EndMT and the Functional Assessment of EndMT Effectors using CRISPR/Cas9 Gene Editing
07:05

TGF-β-mediated Endothelial to Mesenchymal Transition EndMT and the Functional Assessment of EndMT Effectors using CRISPR/Cas9 Gene Editing

Published on: February 26, 2021

5.7K

Related Experiment Videos

Last Updated: Jan 7, 2026

A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics
08:42

A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics

Published on: September 19, 2016

9.2K
Retinal Explant of the Adult Mouse Retina as an Ex Vivo Model for Studying Retinal Neurovascular Diseases
06:51

Retinal Explant of the Adult Mouse Retina as an Ex Vivo Model for Studying Retinal Neurovascular Diseases

Published on: December 9, 2022

5.1K
TGF-&#946;-mediated Endothelial to Mesenchymal Transition EndMT and the Functional Assessment of EndMT Effectors using CRISPR/Cas9 Gene Editing
07:05

TGF-β-mediated Endothelial to Mesenchymal Transition EndMT and the Functional Assessment of EndMT Effectors using CRISPR/Cas9 Gene Editing

Published on: February 26, 2021

5.7K

Area of Science:

  • Epigenetics
  • Molecular Biology
  • Cardiovascular Science

Background:

  • Vascular senescence drives age-related cardiovascular diseases.
  • Epigenetic control of vascular senescence is not well understood.
  • Lysine acetyltransferase 8 (KAT8) is a key histone acetyltransferase.

Purpose of the Study:

  • Investigate KAT8's role in endothelial cell homeostasis and vascular senescence.
  • Elucidate the epigenetic mechanisms controlling KAT8 in vascular aging.

Main Methods:

  • CRISPR/Cas9 loss-of-function and gain-of-function in endothelial cells and mouse models (C57BL/6J, ApoE-/-).
  • Integrated multi-omics analysis (miRNA-seq, ATAC-seq, RNA-seq).

Main Results:

  • KAT8 expression decreases with age in human vessels, aged rodents, and cell models.
  • KAT8 deficiency worsens aging phenotypes; KAT8 overexpression reduces vascular senescence.
  • hsa-miR-339-3p mediates age-related KAT8 downregulation.
  • KAT8 suppresses vascular senescence via the inhibin beta (INHBA)/TGF-β/P15 pathway.

Conclusions:

  • KAT8 is a critical epigenetic regulator preventing vascular aging.
  • Targeting the KAT8/INHBA pathway offers a potential therapeutic strategy for vascular aging diseases.