Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasma proteomics reveals divergent sex-specific senescence and bone biology signatures across neurodegenerative diseases.

bioRxiv : the preprint server for biology·2026
Same author

Comparison of engagement and outcomes among postpartum individuals with public vs private insurance in a remote blood pressure monitoring program.

American journal of obstetrics & gynecology MFM·2026
Same author

Authors' Reply to: "Comment on 'Does pelvic fixation impact reoperation outcomes for neuromuscular scoliosis surgery? A 10-year matched cohort analysis'".

Spine deformity·2026
Same author

Reoperation rates following spinal epidural abscess evacuation with and without instrumentation: a retrospective matched cohort analysis.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same author

Response to Letter to the Editor concerning "Does pelvic fixation impact reoperation outcomes for neuromuscular scoliosis surgery? A 10-year matched cohort analysis" by Etigunta SK, et al.

Spine deformity·2026
Same author

Pre-analytical guidelines for blood and CSF Biomarkers 2025: Recommendations from the NACC ADRC Biofluid Biomarker Best Practices Workgroup.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Evidence for progressive neurodegeneration in iatrogenic cerebral amyloid angiopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Human brain connectome profiles mediate the relationship between pathology burden and clinical phenotypes in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Kat5 cKO mouse replicates biological domain signatures associated with Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Evaluation of CSF and plasma tau species as fluid surrogate candidates for tau PET in prodromal to moderate Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Associations of self-reported obstructive sleep apnea with cognition and dementia risk in cognitively unimpaired middle-aged adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

Biomarkers.

Andy Liu1, Danielle Simmons1, Frank Longo1

  • 1Stanford University, Stanford, CA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Researchers used advanced diffusion MRI and X-ray scattering to detect myelin degeneration in an Alzheimer's Disease (AD) mouse model. X-ray scattering showed myelin loss in gray matter, complementing MRI's white matter findings.

More Related Videos

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Related Experiment Videos

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Area of Science:

  • Neuroimaging
  • Biophysics
  • Alzheimer's Disease Research

Background:

  • Myelin degeneration is implicated in Alzheimer's Disease (AD), but quantifying these changes is challenging.
  • Diffusion MRI and X-ray scattering offer complementary sensitivities to myelin structure.

Purpose of the Study:

  • To utilize advanced diffusion MRI metrics and X-ray scattering to detect and quantify myelin degeneration in an ex vivo AD mouse model.
  • To compare the sensitivity of diffusion MRI and X-ray scattering in detecting myelin changes in white and gray matter.

Main Methods:

  • Acquisition of diffusion MRI and X-ray scattering data from hAPP mutant and wild-type mouse brains.
  • Calculation of diffusion myelin-sensitive metrics (e.g., radial diffusivity, axonal water fraction) and quantitative myelin mapping using X-ray scattering.
  • Non-linear registration to the Allen Atlas and statistical comparison of white and gray matter regions between groups.

Main Results:

  • Diffusion MRI revealed myelin degeneration in white matter (corpus callosum, alveus) of AD mice, indicated by increased radial diffusivity and reduced axonal water fraction.
  • X-ray scattering detected significantly lower myelin levels in the gray matter (cortex, thalamus) of AD mice.
  • White matter changes were more pronounced with diffusion MRI, while gray matter changes were primarily detected by X-ray scattering.

Conclusions:

  • Both diffusion MRI and X-ray scattering detected imaging changes indicative of compromised myelin levels in AD mouse brains.
  • Diffusion MRI is more sensitive to white matter myelin degeneration, whereas X-ray scattering can detect myelin changes in gray matter where MRI sensitivity is limited.
  • X-ray scattering shows promise for detecting subtle myelin degeneration in AD, particularly in gray matter regions.