Clinical Manifestations.

Area of Science:

• Neuroscience
• Neurology
• Linguistics

Background:

• Primary progressive aphasias (PPA) are neurodegenerative syndromes causing progressive language loss.
• Diagnosis can be challenging, particularly in under-resourced regions like Latin America.
• Limited research exists on PPA in Peru.

Purpose of the Study:

• To characterize the clinical, neuropsychological, and radiological profiles of Peruvian PPA patients.
• To contribute data from a region with limited prior research on PPA.
• To inform diagnostic approaches in resource-limited settings.

Main Methods:

• Retrospective analysis of 22 PPA patients diagnosed at a Lima, Peru center.
• Application of 2011 international consensus criteria for PPA.
• Utilized clinical assessments, neuropsychological testing, and MRI scans.

Main Results:

• The cohort averaged 65.3 years, with 77.3% males.
• Semantic and non-fluent variants were most common (9 patients each).
• Significant differences in the Letters: P task performance were noted between PPA subtypes; 60% of non-fluent PPA cases showed diffuse atrophy on MRI.

Conclusions:

• This study provides essential data on PPA characteristics in Peruvian patients.
• Highlights the need for comprehensive evaluations to improve PPA diagnosis in diverse populations.
• Further research is required for a deeper understanding of PPA in this region.