[The overall study protocol for the West China Bone Health Cohort]

As China's population ages at an increasingly rapid rate, osteoporosis, a disease closely associated with aging, has emerged as a significant threat to healthy aging. Developing an accurate prediction model for the risk of osteoporosis onset remains crucial for the early identification of individuals at high risk. Our research team aims to establish the West China Bone Health Cohort in both hospital and community settings. We plan to collect phenotypic and omics data through questionnaires, carry out physical examinations and clinical imaging, collect biological samples, and perform laboratory tests. Our goal is to map bone mass change trajectories, identify risk factors influencing osteoporosis, and uncover key molecular biomarkers through a multi-omics approach. We anticipate that our work will enable the early detection, prevention, and intervention for osteoporosis. In this paper, we aimed to provide an overview of the research background, objectives, methods, quality control measures, and progress for our cohort, which is currently under construction.