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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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Clinical Manifestations.

Cristina A F Román1, Anny Reyes2

  • 1Keck School of Medicine of USC, Los Angeles, CA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Excluding individuals with neurological disorders from aging research limits understanding. Including these groups offers unique insights into cognitive aging and dementia risk, promoting health equity.

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Area of Science:

  • Gerontology
  • Neuroscience
  • Public Health

Background:

  • Aging and dementia research often excludes individuals with neurological/medical disorders, fearing confounding variables.
  • This exclusion limits understanding of aging processes and phenotypic heterogeneity in conditions like Alzheimer's disease.
  • Studies focusing on these populations can provide unique insights into aging and disease mechanisms.

Purpose of the Study:

  • To review existing literature on aging and dementia in individuals with specific neurological/medical disorders.
  • To highlight the limited research in these populations and identify unique aging/dementia-related findings.
  • To propose a framework for inclusive aging and dementia research.

Main Methods:

  • Conducted literature reviews using PubMed and Medline for seven neurological/medical disorders.
  • Searched for terms related to disorders, cognition, neuroimaging, dementia, and psychosocial factors.
  • Excluded reviews, meta-analyses, dissertations, and abstracts; focused on primary research variables.

Main Results:

  • Research on aging/dementia in groups like multiple sclerosis and traumatic brain injury is limited.
  • Evidence suggests accelerated aging and increased dementia risk in several neurological/medical disorders.
  • Unique cognitive profiles exist, and chronicity impacts cognitive outcomes; health disparities are exacerbated.

Conclusions:

  • Focusing on neurological/medical populations in aging/dementia research yields valuable insights into cognitive, neural, and psychosocial mechanisms.
  • Including these underrepresented groups is essential for scientific advancement in aging and dementia.
  • Future research incorporating these populations will drive the development of effective interventions.