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Published on: September 20, 2018
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Clinical Manifestations
Tiffany J Pan1,2, Hui Jue Wang1,2, Nathan Herrmann1,2
1Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
Summary
Nabilone effectively reduced anxiety and depression symptoms in patients with moderate-severe Alzheimer's disease (AD). Further research is needed to understand its effects on appetite changes in AD patients.
Area of Science:
- Neuroscience
- Gerontology
- Psychiatry
Background:
- Neuropsychiatric symptoms (NPS) significantly impact Alzheimer's disease (AD) patients' quality of life.
- Nabilone demonstrated potential in treating agitation in a prior AD trial.
- This study investigates nabilone's effects on non-agitation NPS in moderate-to-severe AD.
Purpose of the Study:
- To explore the efficacy of nabilone in alleviating non-agitation NPS in moderate-to-severe Alzheimer's disease.
- To analyze nabilone's impact on anxiety, depression, and appetite/eating habits in AD patients.
Main Methods:
- A randomized crossover trial involving 39 moderate-to-severe AD patients with agitation.
- Participants received nabilone and placebo in separate 6-week treatment phases with a 1-week washout.
- Linear mixed models analyzed changes in Neuropsychiatric Inventory-Nursing Home version (NPI-NH) sub-scales.
Main Results:
- Nabilone treatment led to significant decreases in anxiety and depression compared to placebo.
- Greater changes in appetite/eating habits were observed with nabilone.
- Higher baseline scores for anxiety, depression, and appetite predicted greater symptom reduction during treatment.
Conclusions:
- Nabilone shows potential for alleviating anxiety and depression in moderate-to-severe AD patients.
- Exploratory findings suggest nabilone may improve mood-related symptoms beyond agitation.
- The impact of nabilone on appetite requires further investigation due to unclear changes.
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